How To Prepare Simulated Saliva Fluid

Simulated Saliva Fluid

Purpose: Used for evaluating drug dissolution in the oral cavity.

Procedure:

1. Dissolve 0.4 g NaCl, 0.4 g KCl, 0.795 g CaCl₂·2H₂O, and 0.69 g NaH₂PO₄·2H₂O in 900 ml distilled water.

2. Adjust pH to 6.8 with NaOH.

3. Make up the volume to 1000 ml with distilled water.

4. Store at room temperature.